Si306
Product Specifications
UNSPSC Description
Si306 is a Src inhibitor with antitumor activity. Si306 reduces the phosphorylation of focal adhesion kinase (FAK) and the expression of epidermal growth factor receptor (EGFR), and inhibits the invasion of human glioblastoma (GBM)[1].
Target Antigen
EGFR; FAK; Src
Type
Reference compound
Related Pathways
JAK/STAT Signaling;Protein Tyrosine Kinase/RTK
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/si306.html
Smiles
BrC1=CC(NC2=NC(SCCN3CCOCC3)=NC4=C2C=NN4CC(Cl)C5=CC=CC=C5)=CC=C1
Molecular Weight
573.94
References & Citations
[1]Nešović, et al. "Src Inhibitors Pyrazolo [3, 4-d] pyrimidines, Si306 and Pro-Si306, inhibit focal adhesion kinase and suppress human glioblastoma invasion in vitro and in vivo." Cancers 12.6 (2020): 1570.
Shipping Conditions
Room temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-164527/Si306-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-164527/
Clinical Information
No Development Reported
CAS Number
1640012-88-9
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