Si306

Si306 is a Src inhibitor with antitumor activity. Si306 reduces the phosphorylation of focal adhesion kinase (FAK) and the expression of epidermal growth factor receptor (EGFR), and inhibits the invasion of human glioblastoma (GBM) [1].

Product Specifications

CAS Number

[1640012-88-9]

UNSPSC

12352005

Target

EGFR; FAK; Src

Type

Reference compound

Related Pathways

JAK/STAT Signaling; Protein Tyrosine Kinase/RTK

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/si306.html

Smiles

BrC1=CC(NC2=NC(SCCN3CCOCC3)=NC4=C2C=NN4CC(Cl)C5=CC=CC=C5)=CC=C1

Molecular Formula

C25H26BrClN6OS

Molecular Weight

573.94

References & Citations

[1]Nešović, et al. "Src Inhibitors Pyrazolo [3, 4-d] pyrimidines, Si306 and Pro-Si306, inhibit focal adhesion kinase and suppress human glioblastoma invasion in vitro and in vivo." Cancers 12.6 (2020) : 1570.