Salcaprozate (sodium)

Salcaprozate sodium (SNAC), an oral absorption promoter, and has the potential as a delivery agent for oral forms of heparin and insulin. Salcaprozate sodium could increase passive transcellular permeation across small intestinal epithelia based on increased lipophilicity arising from non-covalent macromolecule complexation[1][2].

Product Specifications

CAS Number

[203787-91-1]

Product Name Alternative

SNAC

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Biochemical Assay Reagents

Type

Reference compound

Related Pathways

Others

Field of Research

Others

Assay Protocol

https://www.medchemexpress.com/salcaprozate-sodium.html

Concentration

10mM

Purity

99.94

Solubility

DMSO : 50 mg/mL (ultrasonic)

Smiles

O=C(O[Na])CCCCCCCNC(C1=CC=CC=C1O)=O

Molecular Formula

C15H20NNaO4

Molecular Weight

301.32

Precautions

H302, H315, H319, H335

References & Citations

[1]Riley MGI, et, al. Subchronic oral toxicity of salcaprozate sodium (SNAC) in Sprague-Dawley and Wistar rats. Int J Toxicol. Jul-Aug 2009; 28 (4) :278-93.|[2]Twarog C, et, al. Intestinal Permeation Enhancers for Oral Delivery of Macromolecules: A Comparison between Salcaprozate Sodium (SNAC) and Sodium Caprate (C 10) . Pharmaceutics. 2019 Feb 13; 11 (2) :78.|[3]Li Y, et, al. Impact of Sodium N-[8- (2-Hydroxybenzoyl) amino]-caprylate on Intestinal Permeability for Notoginsenoside R1 and Salvianolic Acids in Caco-2 Cells Transport and Rat Pharmacokinetics. Molecules. 2018 Nov 16; 23 (11) :2990.