IFSP1
IFSP1 is a potent, selective and glutathione-independent inhibitor of ferroptosis suppressor protein 1 (FSP1) (AIFM2) with an EC50 of 103 nM. iFSP1 selectively induces ferroptosis in GPX4-knockout cells which overexpressed FSP1. iFSP1 is able to sensitize a variety of human cancer cell lines to the ferroptosis inducer, such as (1S,3R) -RSL3 (HY-100218A) [1].
Product Specifications
CAS Number
[150651-39-1]
UNSPSC
12352005
Hazard Statement
H302, H312, H315, H319, H332, H335
Target
Ferroptosis; Ligands for Target Protein for PROTAC
Type
Reference compound
Related Pathways
Apoptosis; PROTAC
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/ifsp1.html
Purity
99.96
Solubility
DMSO : 11.67 mg/mL (ultrasonic)
Smiles
N#CC1=C(N)N2C3=CC=CC=C3N=C2C(C#N)=C1C4=CC=C(C)C=C4
Molecular Formula
C20H13N5
Molecular Weight
323.35
Precautions
H302, H312, H315, H319, H332, H335
References & Citations
[1]Doll S, et al. FSP1 is a glutathione-independent ferroptosis suppressor.Nature. 2019 Nov;575 (7784) :693-698.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
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