2-Hydroxy-4- (methylthio) butyric acid

2-Hydroxy-4- (methylthio) butyric acid (2-Hydroxy-4- (Methylthio) -Butanoic Acid) is an orally active source of methionine. 2-Hydroxy-4- (methylthio) butyric acid reduces the expression of multiple mRNAs (BHMT, MTR, MAT1A, SAHH, and PCK1) . 2-Hydroxy-4- (methylthio) butyric acid increases milk production in periparturient cows[1][2][3][4][5].

Product Specifications

CAS Number

[583-91-5]

UNSPSC

12352211

Hazard Statement

H315, H318, H412

Target

Amino Acid Derivatives

Type

Natural Products

Related Pathways

Others

Field of Research

Others

Assay Protocol

https://www.medchemexpress.com/2-hydroxy-4-methylthio-butyric-acid.html

Concentration

10mM

Purity

88.0

Solubility

DMSO : ≥ 200 mg/mL

Smiles

O=C(C(CCSC)O)O

Molecular Formula

C5H10O3S

Molecular Weight

150.20

Precautions

H315, H318, H412

References & Citations

[1]Fang Z, et al. Methionine metabolism in piglets Fed DL-methionine or its hydroxy analogue was affected by distribution of enzymes oxidizing these sources to keto-methionine. J Agric Food Chem. 2010 Feb 10;58 (3) :2008-14. |[2]St-Pierre NR, et al. Effects of 2-hydroxy-4- (methylthio) butanoic acid (HMB) and its isopropyl ester on milk production and composition by Holstein cows. J Dairy Sci. 2005 Jul;88 (7) :2487-97. |[3]Noftsger SM, et al. Effects of 2-hydroxy-4- (methylthio) butanoic acid (HMB) on microbial growth in continuous culture. J Dairy Sci. 2003 Aug;86 (8) :2629-36. |[4]Piepenbrink MS, et al. Feeding 2-hydroxy-4- (methylthio) -butanoic acid to periparturient dairy cows improves milk production but not hepatic metabolism. J Dairy Sci. 2004 Apr;87 (4) :1071-84. |[5]Zhang Q, et al. The effect of increasing concentrations of dl-methionine and 2-hydroxy-4- (methylthio) butanoic acid on hepatic genes controlling methionine regeneration and gluconeogenesis. J Dairy Sci. 2016 Oct;99 (10) :8451-8460.