NLS-StAx-h
NLS-StAx-h is a selective, cell permeable, stapled peptide Wnt signaling inhibitor with an IC50 of 1.4 μM. NLS-StAx-h efficiently inhibits β-catenin-transcription factor interactions. NLS-StAx-h shows anti-proliferation of cancer cells[1][2].
Product Specifications
CAS Number
2872559-21-0
UNSPSC
12352209
Target
Wnt; β-catenin
Type
Peptides
Related Pathways
Stem Cell/Wnt
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/nls-stax-h.html
Solubility
10 mM in DMSO
Smiles
O=C(N1[C@@H](CCC1)C(N[C@@H](CCCCNC(N)=N)C(N[C@@]2(C(N[C@@](C(N[C@H](C(N[C@H](C(N[C@@](C)(CCC/C=C/CCC2)C(N[C@H](C(N[C@@H](C(C)C)C(N[C@@H](CCCCNC(N)=N)C(N[C@@H](CCCCNC(N)=N)C(N[C@@H](C(C)C)C(N[C@H](C(N[C@H](C(N)=O)CCCCNC(N)=N)=O)CC3=CNC4=CC=CC=C34)=O)=O)=O)=O)=O)CC5=CN=CN5)=O)=O)CC(O)=O)=O)CC(C)C)=O)([H])[C@@H](C)CC)=O)C)=O)=O)[C@@H](NC([C@H](CCCCNC(N)=N)NC([C@H](CCCCNC(N)=N)NC(COCCOCCNC([C@H](C(C)C)NC([C@H](CCCCN)NC([C@H](CCCNC(N)=N)NC([C@H](CCCCN)NC([C@H](CCCCN)NC([C@H](CCCCN)NC([C@@H]6CCCN6)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)CC7=CNC8=CC=CC=C78
Molecular Formula
C161H275N55O29
Molecular Weight
3445.25
References & Citations
[1]Laura Dietrich, et al. Cell Permeable Stapled Peptide Inhibitor of Wnt Signaling That Targets β-Catenin Protein-Protein Interactions|[2]ang Z, et al. Direct targeting of β-catenin in the Wnt signaling pathway: Current progress and perspectives. Med Res Rev. 2021 Jul;41 (4) :2109-2129.
Shipping Conditions
Room temperature
Scientific Category
Peptides
Clinical Information
No Development Reported
Frequently Asked Questions
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