Cyclamic acid

Cyclamic acid (Cyclamate) is a commonly used sweetener. Cyclamic acid sodium is toxic to osteoblasts and can inhibit cell proliferation, induce apoptosis and reduce cell mineralization. Cyclamic acid sodium causes focal necrosis of bladder organs in rats in vitro, which can promote bladder cancer, but some studies have shown that low doses of Cyclamic acid sodium have no carcinogenic effect. In addition, Cyclamic acid sodium has no effect on insulin and glucagon secretion induced by arginine[1][2][3][4][5].

Product Specifications

CAS Number

[100-88-9]

Product Name Alternative

Cyclohexylsulfamic acid; Cyclamate

UNSPSC

12352211

Hazard Statement

H302, H315, H319, H335

Target

Apoptosis; Necroptosis

Type

Reference compound

Related Pathways

Apoptosis

Field of Research

Cancer; Metabolic Disease

Assay Protocol

https://www.medchemexpress.com/cyclamic-acid.html

Concentration

10mM

Purity

99.82

Solubility

DMSO : 100 mg/mL (ultrasonic) |H2O : ≥ 100 mg/mL

Smiles

O=S(O)(NC1CCCCC1)=O

Molecular Formula

C6H13NO3S

Molecular Weight

179.24

Precautions

H302, H315, H319, H335

References & Citations

[1]Leban I, et, al. Structures of artificial sweeteners--cyclamic acid and sodium cyclamate with other cyclamates. Acta Crystallogr B. 2007 Jun;63 (Pt 3) :418-25.|[2]Chen Z, et al. Toxicity of food sweetener-sodium cyclamate on osteoblasts cells. Biochem Biophys Res Commun. 2019 Jan 8;508 (2) :507-511. |[3]Bopp BA, et al. Toxicological aspects of cyclamate and cyclohexylamine. Crit Rev Toxicol. 1986;16 (3) :213-306.|[4]Usami M, et al. Effect of cyclamate sodium, saccharin sodium and stevioside on arginine-induced insulin and glucagon secretion in the isolated perfused rat pancreas. Horm Metab Res. 1980 Dec;12 (12) :705-6.|[5]Knowles MA, et al. Induction of morphological changes in the urothelium of cultured adult rat bladder by sodium saccharin and sodium cyclamate. Carcinogenesis. 1986 May;7 (5) :767-74.