L-Canaline
Product Specifications
UNSPSC Description
L-Canaline is a nonprotein amino acid stored in many leguminous plants. L-Canaline is a cytotoxic metabolite catalyzed by L-canavanine and its arginase. L-Canaline is a potent and irreversible inhibitor of ornithine aminotransferase. L-Canaline inhibits the growth of the malaria parasite Plasmodium falciparum with an IC50 of 297 nM. L-Canaline has anticancer and antiproliferative effects[1][2][3].
Target Antigen
Endogenous Metabolite; Parasite
Type
Natural Products
Related Pathways
Anti-infection;Metabolic Enzyme/Protease
Field of Research
Cancer; Infection
Assay Protocol
https://www.medchemexpress.com/l-canaline.html
Purity
95.0
Solubility
DMSO : 1 mg/mL (ultrasonic;warming)
Smiles
N[C@@H](CCON)C(O)=O
Molecular Weight
134.13
References & Citations
[1]Bence AK, et al. The antiproliferative and immunotoxic effects of L-canavanine and L-canaline. Anticancer Drugs. 2002 Mar;13(3):313-20.|[2]Rosenthal GA. L-canaline: a potent antimetabolite and anti-cancer agent from leguminous plants. Life Sci. 1997;60(19):1635-41.|[3]Berger BJ. Antimalarial activities of aminooxy compounds. Antimicrob Agents Chemother. 2000 Sep;44(9):2540-2.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-129476/L-Canaline-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-129476/L-Canaline-SDS-MedChemExpress.pdf
Clinical Information
No Development Reported
CAS Number
496-93-5
Available Sizes
Curated Selection
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