L-Canaline

L-Canaline is a nonprotein amino acid stored in many leguminous plants. L-Canaline is a cytotoxic metabolite catalyzed by L-canavanine and its arginase. L-Canaline is a potent and irreversible inhibitor of ornithine aminotransferase. L-Canaline inhibits the growth of the malaria parasite Plasmodium falciparum with an IC50 of 297 nM. L-Canaline has anticancer and antiproliferative effects[1][2][3].

Product Specifications

CAS Number

[496-93-5]

UNSPSC

12352211

Hazard Statement

H302, H312, H315, H318, H332, H335

Target

Endogenous Metabolite; Parasite

Type

Natural Products

Related Pathways

Anti-infection; Metabolic Enzyme/Protease

Applications

COVID-19-immunoregulation

Field of Research

Cancer; Infection

Assay Protocol

https://www.medchemexpress.com/l-canaline.html

Purity

95.0

Solubility

DMSO : 1 mg/mL (ultrasonic; warming)

Smiles

N[C@@H](CCON)C(O)=O

Molecular Formula

C4H10N2O3

Molecular Weight

134.13

Precautions

H302, H312, H315, H318, H332, H335

References & Citations

[1]Bence AK, et al. The antiproliferative and immunotoxic effects of L-canavanine and L-canaline. Anticancer Drugs. 2002 Mar;13 (3) :313-20.|[2]Rosenthal GA. L-canaline: a potent antimetabolite and anti-cancer agent from leguminous plants. Life Sci. 1997;60 (19) :1635-41.|[3]Berger BJ. Antimalarial activities of aminooxy compounds. Antimicrob Agents Chemother. 2000 Sep;44 (9) :2540-2.