BIA 10-2474

BIA 10-2474 is an inhibitor of fatty acid amide hydrolase (FAAH) with IC50 values of 50 to 70mg/kg in various rat brain regions.

Product Specifications

CAS Number

[1233855-46-3]

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Autophagy; FAAH

Type

Reference compound

Related Pathways

Autophagy; Metabolic Enzyme/Protease; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/BIA-10-2474.html

Purity

98.74

Solubility

DMSO : 2.2 mg/mL (ultrasonic)

Smiles

O=C(N1C=C(C2=C[N+]([O-])=CC=C2)N=C1)N(C3CCCCC3)C

Molecular Formula

C16H20N4O2

Molecular Weight

300.36

Precautions

H302, H315, H319, H335

References & Citations

[1]Tong J, et al. Inhibition of fatty acid amide hydrolase by BIA 10-2474 in rat brain. J Cereb Blood Flow Metab. 2016 Sep 20.|[2]Kaur R, et al. What failed BIA 10-2474 Phase I clinical trial? Global speculations and recommendations for future Phase I trials. J Pharmacol Pharmacother. 2016 Jul-Sep;7 (3) :120-6