TMU 35435
Product Specifications
UNSPSC Description
TMU 35435 is a histone deacetylase (HDAC) inhibitor. TMU-35435 inhibits the NHEJ pathway through ubiquitination of DNA-dependent protein kinase catalytic subunit (DNA-PKcs). In addition, TMU 35435 enhances radiosensitivity by inducing misfolded protein aggregation and autophagy in TNBC[1][2].
Target Antigen
Autophagy; HDAC
Type
Reference compound
Related Pathways
Autophagy;Cell Cycle/DNA Damage;Epigenetics
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/tmu-35435.html
Smiles
O=C(C1=CC=CC2=C1N=C3C(C)=CC=CC3=C2)NCCCCCCC(NO)=O
Molecular Weight
379.45
References & Citations
[1]Huiwen Chiu, et al. "A new histone deacetylase inhibitor enhances radiation sensitivity through the induction of misfolded protein aggregation and autophagy in triple-negative breast cancer." Cancers 11.11 (2019): 1703.|[2]Yuanhua Wu, et al. "A novel histone deacetylase inhibitor TMU-35435 enhances etoposide cytotoxicity through the proteasomal degradation of DNA-PKcs in triple-negative breast cancer." Cancer letters 400 (2017): 79-88.
Shipping Conditions
Room temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-164539/TMU-35435-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-164539/
Clinical Information
No Development Reported
CAS Number
2231800-32-9
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