Tat-NR2B9c (TFA)
Product Specifications
UNSPSC Description
Tat-NR2B9c TFA (Tat-NR2Bct TFA) is a postsynaptic density-95 (PSD-95) inhibitor, with EC50 values of 6.7 nM and 670 nM for PSD-95d2 (PSD-95 PDZ domain 2) and PSD-95d1, respectively. Tat-NR2B9c TFA disrupts the PSD-95/NMDAR interaction, inhibiting NR2A and NR2B binding to PSD-95 with IC50 values of 0.5 μM and 8 μM, respectively. Tat-NR2B9c TFA also inhibits neuronal nitric oxide synthase (nNOS)/PSD-95 interaction, and possesses neuroprotective efficacy[1].
Target Antigen
iGluR; NO Synthase
Type
Peptides
Related Pathways
Immunology/Inflammation;Membrane Transporter/Ion Channel;Neuronal Signaling
Applications
Neuroscience-Neurodegeneration
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/tat-nr2b9c-tfa.html
Purity
99.67
Solubility
H2O : ≥ 50 mg/mL
Smiles
O=C(NCC(N[C@@H](CCCNC(N)=N)C(N[C@@H](CCCCN)C(N[C@@H](CCCCN)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CCC(N)=O)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CCCCN)C(N[C@@H](CC(C)C)C(N[C@@H](CO)C(N[C@@H](CO)C(N[C@@H]([C@@H](C)CC)C(N[C@@H](CCC(O)=O)C(N[C@@H](CO)C(N[C@@H](CC(O)=O)C(N[C@@H](C(C)C)C(O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)[C@H](CC1=CC=C(C=C1)O)N.OC(C(F)(F)F)=O
Molecular Weight
2632.90
References & Citations
[1]Cui H, et al. PDZ protein interactions underlying NMDA receptor-mediated excitotoxicity and neuroprotection by PSD-95 inhibitors. J Neurosci. 2007 Sep 12;27(37):9901-15.|[2]Fan J, et al. P38 MAPK is involved in enhanced NMDA receptor-dependent excitotoxicity in YAC transgenic mouse model of Huntington disease. Neurobiol Dis. 2012 Mar;45(3):999-1009.Behav Brain Res. 7 January 2022, 113537.|Biochem Biophys Res Commun. 2024 May 8:720:150076.|J Cereb Blood Flow Metab. 2019 Aug;39(8):1588-1601. |J Neuropathol Exp Neurol. 2020 Jul 1;79(7):800-808.|Neuropharmacology. 2024 Mar 21:109905.|Neuroreport. 2021 Sep 8;32(13):1122-1127.|PLoS One. 2020 Mar 3;15(3):e0229499. |Sci Rep. 2018 May 18;8(1):7848.
Shipping Conditions
Blue Ice
Storage Conditions
-80°C, 2 years; -20°C, 1 year (Powder, sealed storage, away from moisture)
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-P0117A/Tat-NR2B9c-TFA-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-P0117A/Tat-NR2B9c-TFA-SDS-MedChemExpress.pdf
Clinical Information
No Development Reported
CAS Number
1834571-04-8
Available Sizes
Curated Selection
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