Teriflunomide impurity 3

Teriflunomide impurity 3 (4-Amino-N- (4-trifluoromethylphenyl) benzamide) is a selective COX-1 inhibitor with an IC50 of 30 μM. Teriflunomide impurity 3 is less active against COX-2 (IC50>100 μM) [1].

Product Specifications

CAS Number

[1011244-72-6]

Product Name Alternative

4-Amino-N- (4-trifluoromethylphenyl) benzamide

UNSPSC

12352005

Hazard Statement

H315-H319-H335

Target

COX

Type

Reference compound

Related Pathways

Immunology/Inflammation

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/teriflunomide-impurity-3.html

Purity

99.75

Solubility

DMSO : 250 mg/mL (ultrasonic)

Smiles

O=C(NC1=CC=C(C(F)(F)F)C=C1)C2=CC=C(N)C=C2

Molecular Formula

C14H11F3N2O

Molecular Weight

280.25

Precautions

P261-P264-P271-P280-P302+P352-P304+P340-P305+P351+P338-P362+P364-P403+P233-P405-P501

References & Citations

[1]Hiroki Kakuta, et al. Cyclooxygenase-1-selective inhibitors are attractive candidates for analgesics that do not cause gastric damage. design and in vitro/in vivo evaluation of a benzamide-type cyclooxygenase-1 selective inhibitor. J Med Chem. 2008 Apr 24;51 (8) :2400-11.