VRK-IN-1
VRK-IN-1 is a potent and selective inhibitor of vaccinia-related kinases 1 (VRK1), with an IC50 of 150 nM. VRK1 is human Ser/Thr protein kinases associated with increased cell division and neurological disorders[1].
Product Specifications
CAS Number
[2378855-09-3]
UNSPSC
12352005
Target
Ser/Thr Protease
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/vrk-in-1.html
Concentration
10mM
Purity
99.47
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
FC1=C(O)C(F)=CC(C2=C(C)N=CC(C3=CC(F)=C(O)C(F)=C3)=C2)=C1
Molecular Formula
C18H11F4NO2
Molecular Weight
349.28
References & Citations
[1]Serafim RAM, et, al. Development of Pyridine-based Inhibitors for the Human Vaccinia-related Kinases 1 and 2. ACS Med Chem Lett. 2019 Aug 19;10 (9) :1266-1271.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Curated Selection
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