VRK-IN-1

VRK-IN-1 is a potent and selective inhibitor of vaccinia-related kinases 1 (VRK1), with an IC50 of 150 nM. VRK1 is human Ser/Thr protein kinases associated with increased cell division and neurological disorders[1].

Product Specifications

CAS Number

[2378855-09-3]

UNSPSC

12352005

Target

Ser/Thr Protease

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/vrk-in-1.html

Concentration

10mM

Purity

99.47

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

FC1=C(O)C(F)=CC(C2=C(C)N=CC(C3=CC(F)=C(O)C(F)=C3)=C2)=C1

Molecular Formula

C18H11F4NO2

Molecular Weight

349.28

References & Citations

[1]Serafim RAM, et, al. Development of Pyridine-based Inhibitors for the Human Vaccinia-related Kinases 1 and 2. ACS Med Chem Lett. 2019 Aug 19;10 (9) :1266-1271.