VU0155069

VU0155069 (CAY10593), is a selective phospholipase D1 (PLD1) inhibitor with an IC50 value of 46 nM in vitro. VU0155069 (CAY10593) strongly inhibits the invasive migration of several cancer cell lines in transwell assays[1][2].

Product Specifications

CAS Number

[1130067-06-9]

Product Name Alternative

CAY10593

UNSPSC

12352005

Target

Phospholipase

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/vu0155069.html

Purity

98.55

Solubility

DMSO : 50 mg/mL (ultrasonic)

Smiles

O=C(C1=CC=C2C=CC=CC2=C1)N[C@@H](C)CN3CCC(N4C5=CC=C(Cl)C=C5NC4=O)CC3

Molecular Formula

C26H27ClN4O2

Molecular Weight

462.97

References & Citations

[1]Scott SA, et al. Design of isoform-selective phospholipase D inhibitors that modulate cancer cell invasiveness. Nat Chem Biol. 2009 Feb;5 (2) :108-17.|[2]Lewis JA, et al. Design and synthesis of isoform-selective phospholipase D (PLD) inhibitors. Part I: Impact of alternative halogenated privileged structures for PLD1 specificity. Bioorg Med Chem Lett. 2009 Apr 1;19 (7) :1916-20.|[3]Barclay Z, et al. Attenuated PLD1 association and signalling at the H452Y polymorphic form of the 5-HT (2A) receptor. Cell Signal. 2013 Apr;25 (4) :814-21.