Methimazole

Methimazole (Thiamazole) is an anti-thyroid agent, which blocks thyroid hormone production from the thyroid gland. Metamizol can cause hepatotoxicity[1][2][4].

Product Specifications

CAS Number

[60-56-0]

Product Name Alternative

Thiamazole

UNSPSC

12352005

Hazard Statement

H302, H317, H319

Target

Thyroid Hormone Receptor

Type

Reference compound

Related Pathways

Vitamin D Related/Nuclear Receptor

Field of Research

Endocrinology; Cancer

Assay Protocol

https://www.medchemexpress.com/methimazole.html

Purity

99.97

Solubility

DMSO : ≥ 100 mg/mL|H2O : ≥ 50 mg/mL

Smiles

S=C1NC=CN1C

Molecular Formula

C4H6N2S

Molecular Weight

114.17

Precautions

H302, H317, H319

References & Citations

[1]Heidari R, et, al. Effects of Enzyme Induction and/or Glutathione Depletion on Methimazole-Induced Hepatotoxicity in Mice and the Protective Role of N-Acetylcysteine. Adv Pharm Bull. 2014;4 (1) :21-8.|[2]Crescioli C, et al. Methimazole inhibits CXC chemokine ligand 10 secretion in human thyrocytes. J Endocrinol. 2007 Oct;195 (1) :145-55.|[3]Tatara MR, et al. Effects of long-term oral administration of methimazole on femur and tibia properties in male Wistar rats. Biomed Pharmacother. 2017 Oct;94:124-128.|[4]Reza Heidari, et al. Mechanisms of methimazole cytotoxicity in isolated rat hepatocytes. Drug Chem Toxicol. 2013 Oct;36 (4) :403-11.