Nalidixic acid (sodium salt)

Nalidixic acid sodium salt, a quinolone antibiotic, is effective against both gram-positive and gram-negative bacteria. Nalidixic acid acts in a bacteriostatic manner in lower concentrations and is bactericidal in higher concentrations. Nalidixic acid inhibits a subunit of DNA gyrase and topoisomerase IV and reversibly blocks DNA replication in susceptible bacteria[1][2].

Product Specifications

CAS Number

[3374-05-8]

UNSPSC

12352005

Hazard Statement

H302, H317, H334

Target

Antibiotic; Bacterial; Topoisomerase

Type

Reference compound

Related Pathways

Anti-infection; Cell Cycle/DNA Damage

Applications

COVID-19-anti-virus

Field of Research

Infection

Assay Protocol

https://www.medchemexpress.com/nalidixic-acid-sodium-salt.html

Purity

99.83

Solubility

H2O : 116.67 mg/mL (ultrasonic)

Smiles

O=C(C1=CN(CC)C2=NC(C)=CC=C2C1=O)O[Na]

Molecular Formula

C12H11N2NaO3

Molecular Weight

254.22

Precautions

H302, H317, H334

References & Citations

[1]G Y LESHER, et al. 1,8-NAPHTHYRIDINE DERIVATIVES. A NEW CLASS OF CHEMOTHERAPEUTIC AGENTS. J Med Pharm Chem. 1962 Sep;91:1063-5.|[2]Anna Fàbrega, et al. Mechanism of Action of and Resistance to Quinolones. Microb Biotechnol