Heclin
Product Specifications
UNSPSC Description
Heclin is a HECT E3 ubiquitin ligases inhibitor. Heclin inhibits Smurf2, Nedd4, WWP1 (IC50 values are 6.8, 6.3, 6.9 μM) and can be used for the research of gastric cancer[1][2][3].
Target Antigen
Akt; E1/E2/E3 Enzyme; MyD88
Type
Reference compound
Related Pathways
Immunology/Inflammation;Metabolic Enzyme/Protease;PI3K/Akt/mTOR
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Others
Assay Protocol
https://www.medchemexpress.com/heclin.html
Purity
98.21
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
CC(C(C=C1)=CC=C1NC(/C=C/C2=CC=C(CC)O2)=O)=O
Molecular Weight
283.32
References & Citations
[1]Wang K, et al. Targeting the E3 ligase NEDD4 as a novel therapeutic strategy for IGF1 signal pathway-driven gastric cancer [J]. Oncogene, 2023, 42(14): 1072-1087.|[2]Su B C, Chen J Y. Antimicrobial peptide epinecidin-1 modulates MyD88 protein levels via the proteasome degradation pathway [J]. Marine Drugs, 2017, 15(11): 362.|[3]Mund T, et al. Peptide and small molecule inhibitors of HECT-type ubiquitin ligases [J]. Proceedings of the National Academy of Sciences, 2014, 111(47): 16736-16741.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-110204/Heclin-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-110204/Heclin-SDS-MedChemExpress.pdf
Clinical Information
No Development Reported
CAS Number
890605-54-6
Available Sizes
Curated Selection
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