EEDi-5273
EEDi-5273 (APG-5918) is a potent and orally active embryonic ectoderm development (EED) inhibitor with an IC50 of 0.2 nM. EEDi-5273 can inhibit the polycomb repressive complex 2 (PRC2) activity and block trimethylation of histone H3 lysine 27. EEDi-5273 can be used for the research of cancer, such as ovarian cancer[1].
Product Specifications
CAS Number
[2585648-55-9]
Product Name Alternative
APG-5918
UNSPSC
12352005
Target
Histone Methyltransferase
Type
Reference compound
Related Pathways
Epigenetics
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/eedi-5273.html
Concentration
10mM
Purity
99.09
Solubility
DMSO : 25 mg/mL (ultrasonic)
Smiles
CC(N1CC2=CC(C(F)(F)F)=NC=C2C3=CN=C(N4C=NC(C1=O)=C34)NCC5=C6CCOC6=CC=C5F)C
Molecular Formula
C26H22F4N6O2
Molecular Weight
526.49
References & Citations
[1]Rej RK, et al. Discovery of EEDi-5273 as an Exceptionally Potent and Orally Efficacious EED Inhibitor Capable of Achieving Complete and Persistent Tumor Regression. J Med Chem. 2021 Oct 14;64 (19) :14540-14556.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Phase 1
Available Sizes
Curated Selection
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