Keap1-Nrf2-IN-9
Keap1-Nrf2-IN-9 (Compound 11) is a potent Keap1-Nrf2 PPI (Keap1-Nrf2 protein-protein interaction) inhibitor with an IC50 of 0.575 μM. Keap1-Nrf2-IN-9 increases the expression of Nrf2 target genes including heme oxygenase 1 (Hmox1), glutathione S-transferase P (GstP), and glutamate-cysteine ligase catalytic (Gclc) and modulatory (Gclm) subunits. Keap1-Nrf2-IN-9 shows no cytotoxic activity in ARPE19 cells[1].
Product Specifications
CAS Number
[2769963-24-6]
UNSPSC
12352005
Target
Keap1-Nrf2
Type
Reference compound
Related Pathways
NF-κB
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology; Neurological Disease
Assay Protocol
https://www.medchemexpress.com/keap1-nrf2-in-9.html
Purity
98.52
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O=S(N(CC(O)=O)C1=CC=C(N(CC(O)=O)S(=O)(C2=CC=C(OC)C=C2)=O)C=C1OCC3=CC=CC=C3)(C4=CC=C(OC)C=C4)=O
Molecular Formula
C31H30N2O11S2
Molecular Weight
670.71
References & Citations
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
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