N-myristoyl-RKRTLRRL

N-myristoyl-RKRTLRRL inhibits binding of PKC substrates. N-myristoyl-RKRTLRRL inhibits Ca2+- and phosphatidylserine (PS) -dependent histone phosphorylation with IC50 of 5 μM. histone phosphorylation with IC50 of 80 μM[1][2].

Product Specifications

CAS Number

[152246-40-7]

UNSPSC

12352209

Target

PKC

Type

Peptides

Related Pathways

Epigenetics; TGF-beta/Smad

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/n-myristoyl-rkrtlrrl.html

Purity

99.37

Solubility

DMSO : 50 mg/mL (ultrasonic)

Smiles

CC(C)C[C@@H](C(O)=O)NC([C@H](CCCNC(N)=N)NC([C@H](CCCNC(N)=N)NC([C@H](CC(C)C)NC([C@H]([C@H](O)C)NC([C@H](CCCNC(N)=N)NC([C@H](CCCCN)NC([C@H](CCCNC(N)=N)NC(CCCCCCCCCCCCC)=O)=O)=O)=O)=O)=O)=O)=O

Molecular Formula

C60H117N21O11

Molecular Weight

1308.71

References & Citations

[1]David K Crockett, et al. Identification of proteins from formalin-fixed paraffin-embedded cells by LC-MS/MS. Lab Invest. 2005 Nov;85 (11) :1405-15.|[2]C A O'Brian, et al. A novel N-myristylated synthetic octapeptide inhibits protein kinase C activity and partially reverses murine fibrosarcoma cell resistance to Adriamycin. Invest New Drugs. 1991 May;9 (2) :169-79.