Pomalidomide-C3-adavosertib
Pomalidomide-C3-adavosertib is a rapid and selective PROTAC Wee1 degrader (IC50=3.58 nM) . Pomalidomide-C3-adavosertib shows anti-cancer cell proliferation activity, and induces apoptosis[1].
Product Specifications
CAS Number
2414418-49-6
UNSPSC
12352005
Target
PROTACs; Wee1
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage; PROTAC
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/pomalidomide-c3-adavosertib.html
Purity
99.84
Solubility
DMSO : 50 mg/mL (ultrasonic)
Smiles
O=C1N(CC=C)N(C2=NC(C(O)(C)C)=CC=C2)C3=NC(NC4=CC=C(N5CCN(CCCNC6=CC=CC(C(N7C8CCC(NC8=O)=O)=O)=C6C7=O)CC5)C=C4)=NC=C31
Molecular Formula
C42H45N11O6
Molecular Weight
799.88
References & Citations
[1]Nathanael S. Gray, et al. Degraders of wee1 kinase. WO2020069105A1.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
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