NO-Losartan A
NO-Losartan A (compound 2a) displays vasorelaxing effects, due to the release of NO, and antagonized the vasocontractile effects of Angiotensin II (HY-13948), with potency values similar to that of Losartan (HY-17512) [1].
Product Specifications
CAS Number
[791122-48-0]
UNSPSC
12352005
Hazard Statement
H315, H319, H335
Target
Angiotensin Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein
Applications
Neuroscience-Neuromodulation
Field of Research
Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/no-losartan-a.html
Purity
99.22
Solubility
10 mM in DMSO
Smiles
O=C(OCC1=C(Cl)N=C(CCCC)N1CC2=CC=C(C3=CC=CC=C3C4=NNN=N4)C=C2)C5=CC=CC(CO[N+]([O-])=O)=C5
Molecular Formula
C30H28ClN7O5
Molecular Weight
602.04
Precautions
H315, H319, H335
References & Citations
[1]Maria C Breschi, et al. NO-sartans: a new class of pharmacodynamic hybrids as cardiovascular drugs. J Med Chem. 2004 Nov 4;47 (23) :5597-600.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C (Powder, stored under nitrogen)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Explore Other Products
Discover premium biology products from our extensive collection of 20M+ items
