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Alphitolic acid

Alphitolic acid (Aophitolic acid) is an anti-inflammatory triterpene could found in quercus aliena. Alphitolic acid blocks Akt–NF-κB signaling to induce apoptosis. Alphitolic acid induces autophagy. Alphitolic acid has anti-inflammatory activity and down-regulates the NO and TNF-α production. Alphitolic acid can be used for cancer and inflammation research[1][2][3].

Product Specifications

CAS Number

[19533-92-7]

Product Name Alternative

Aophitolic acid

UNSPSC

12352211

Target

Akt; Apoptosis; Autophagy; NF-κB; TNF Receptor

Type

Natural Products

Related Pathways

Apoptosis; Autophagy; NF-κB; PI3K/Akt/mTOR

Applications

COVID-19-immunoregulation

Field of Research

Cancer; Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/alphitolic-acid.html

Purity

97.0

Solubility

DMSO : 50 mg/mL (ultrasonic)

Smiles

OC([C@]12[C@@]([C@@H](CC2)C(C)=C)([H])[C@]3([H])[C@@](CC1)([C@]4([C@]([C@@]5([C@@](C(C)([C@H]([C@@H](C5)O)O)C)([H])CC4)C)([H])CC3)C)C)=O

Molecular Formula

C30H48O4

Molecular Weight

472.70

References & Citations

[1]Bai LY, et, al. Alphitolic acid, an anti-inflammatory triterpene, induces apoptosis and autophagy in oral squamous cell carcinoma cells, in part, through a p53-dependent pathway. 2015 Jan 22; 18 (2015) :368-378.|[2]Raju R, et, al. Anti-Inflammatory Chemical Profiling of the Australian Rainforest Tree Alphitonia petriei (Rhamnaceae) . Molecules. 2016 Nov 11;21 (11) :1521. |[3]Goity LE, et, al. An HPLC-UV and HPLC-ESI-MS based method for identification of antiinflammatory triterpenoids from the extracts of Ugni molinae. 2013 Jan; 12 (1) :108-116.

Shipping Conditions

Room Temperature

Storage Conditions

4°C (Powder, protect from light)

Scientific Category

Natural Products

Clinical Information

No Development Reported

Available Sizes

Curated Selection

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