NLRP3-IN-17
NLRP3-IN-17 is a potent, selective and orally active NLRP3 inflammasome inhibitor with an IC50 value of 7 nM. NLRP3-IN-17 significantly inhibits NLRP3 dependent IL-1β secretion in mice and can be used for chronic inflammatory diseases research[1].
Product Specifications
CAS Number
2254432-75-0
UNSPSC
12352005
Target
NOD-like Receptor (NLR)
Type
Reference compound
Related Pathways
Immunology/Inflammation
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/nlrp3-in-17.html
Concentration
10mM
Purity
99.23
Solubility
DMSO : 33.33 mg/mL (ultrasonic)
Smiles
N#CN=S(NC(NC1=C(CCC2)C2=CC3=C1CCC3)=O)(C4=CC=C(C)C=C4)=O
Molecular Formula
C21H22N4O2S
Molecular Weight
394.49
References & Citations
[1]Sameer Agarwal, et al. Discovery of N-Cyano-sulfoximineurea Derivatives as Potent and Orally Bioavailable NLRP3 Inflammasome Inhibitors. ACS Med Chem Lett. 2020 Feb 27;11 (4) :414-418.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
NLRP3
Available Sizes
Frequently Asked Questions
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