Radicicol
Radicicol is an inhibitor of Hsp90 with an IC50 value [1]. Radicicol exhibits inhibition on PDK with IC50s of 230 μM (PDK1) and 400 μM (PDK3) . Radicicol is an antifungal and antimalarial antibiotic, impairs mitochondrial replication by targeting P. falciparum topoisomerase VIB[2]. Radicicol is also an inhibitor of fat mass and obesity-associated protein (FTO), with an IC50 value of 16.04 μM[3].
Product Specifications
CAS Number
12772-57-5
Product Name Alternative
Monorden
UNSPSC
12352005
Hazard Statement
H301, H315, H319, H335
Target
Antibiotic; Bacterial; HSP; Parasite
Type
Natural Products
Related Pathways
Anti-infection; Cell Cycle/DNA Damage; Metabolic Enzyme/Protease
Applications
COVID-19-anti-virus
Field of Research
Infection
Assay Protocol
https://www.medchemexpress.com/radicicol.html
Purity
99.96
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
OC1=C2C(CC(/C=C/C=C\[C@@H](O3)[C@H]3C[C@@H](C)OC2=O)=O)=C(Cl)C(O)=C1
Molecular Formula
C18H17ClO6
Molecular Weight
364.78
Precautions
H301, H315, H319, H335
References & Citations
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Natural Products
Clinical Information
No Development Reported
Isoform
HSP90; Plasmodium
Available Sizes
Frequently Asked Questions
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