Radicicol

Radicicol is an inhibitor of Hsp90 with an IC50 value [1]. Radicicol exhibits inhibition on PDK with IC50s of 230 μM (PDK1) and 400 μM (PDK3) . Radicicol is an antifungal and antimalarial antibiotic, impairs mitochondrial replication by targeting P. falciparum topoisomerase VIB[2]. Radicicol is also an inhibitor of fat mass and obesity-associated protein (FTO), with an IC50 value of 16.04 μM[3].

Product Specifications

CAS Number

[12772-57-5]

Product Name Alternative

Monorden

UNSPSC

12352005

Hazard Statement

H301, H315, H319, H335

Target

Antibiotic; Bacterial; HSP; Parasite

Type

Natural Products

Related Pathways

Anti-infection; Cell Cycle/DNA Damage; Metabolic Enzyme/Protease

Applications

COVID-19-anti-virus

Field of Research

Infection

Assay Protocol

https://www.medchemexpress.com/radicicol.html

Purity

99.96

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

OC1=C2C(CC(/C=C/C=C\[C@@H](O3)[C@H]3C[C@@H](C)OC2=O)=O)=C(Cl)C(O)=C1

Molecular Formula

C18H17ClO6

Molecular Weight

364.78

Precautions

H301, H315, H319, H335

References & Citations

[1]Kato M, et al. Distinct structural mechanisms for inhibition of pyruvate dehydrogenase kinase isoforms by AZD7545, dichloroacetate, and radicicol. Structure. 2007 Aug;15 (8) :992-1004. Epub 2007 Aug 2.|[2]Chalapareddy S, et al. Radicicol confers mid-schizont arrest by inhibiting mitochondrial replication in Plasmodium falciparum. Antimicrob Agents Chemother. 2014 Aug;58 (8) :4341-52.|[3]Wang R, et al. Identification of Natural Compound Radicicol as a Potent FTO Inhibitor. Mol Pharm. 2018 Sep 4;15 (9) :4092-4098.|[4]Sonoda H, et al. The protective effect of radicicol against renal ischemia--reperfusion injury in mice. J Pharmacol Sci. 2010;112 (2) :242-6. |[5]Nascimento TL, et al. Radicicol enhances the regeneration of skeletal muscle injured by crotoxin via decrease of NF-kB activation. Toxicon. 2019 Sep;167:6-9.