Cinnamtannin B-1

Cinnamtannin B-1 is a anthocyanidin. Cinnamtannin B-1 inhibits the osteoclast formation by inhibiting NF-kB signaling pathway and ROS generation. Cinnamtannin B-1 exhibits antioxidant, anti-inflammatory, antitumor and anti-platelet aggregation activities. Cinnamtannin B-1 is orally active[1][2][3].

Product Specifications

CAS Number

[88082-60-4]

UNSPSC

12352005

Target

Apoptosis; NF-κB; Reactive Oxygen Species (ROS)

Type

Natural Products

Related Pathways

Apoptosis; Immunology/Inflammation; Metabolic Enzyme/Protease; NF-κB

Applications

Metabolism-protein/nucleotide metabolism

Field of Research

Cancer; Metabolic Disease

Assay Protocol

https://www.medchemexpress.com/cinnamtannin-b-1.html

Purity

99.16

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

O[C@H]1[C@@H](C2=CC=C(O)C(O)=C2)OC3=C4C(O[C@]5(C6=CC=C(O)C(O)=C6)OC7=CC(O)=CC(O)=C7[C@@]4([H])[C@H]5O)=CC(O)=C3[C@@H]1C8=C9C(C[C@@H](O)[C@@H](C%10=CC=C(O)C(O)=C%10)O9)=C(O)C=C8O

Molecular Formula

C45H36O18

Molecular Weight

864.76

References & Citations

[1]Meng Li, et al. Cinnamtannin B-1 Prevents Ovariectomy-Induced Osteoporosis via Attenuating Osteoclastogenesis and ROS Generation. Front Pharmacol. 2020 Jul 10;11:1023.|[2]Patrick P Carriere, et al. Cinnamtannin B-1 inhibits cell survival molecules and induces apoptosis in colon cancer.Int J Oncol. 2018 Oct;53 (4) :1442-1454.|[3]Fujita K, et al., Cinnamtannin B-1 Promotes Migration of Mesenchymal Stem Cells and Accelerates Wound Healing in Mice. PLoS One. 2015 Dec 11;10 (12) :e0144166.