Cisd2 agonist 2

Cisd2 agonist 2 (compound 6) is a Cisd2 activator (EC50=191 nM), and Cisd2 levels are associated with non-alcoholic fatty liver disease (NAFLD) . Cisd2 agonist 2 has no significant in vivo toxicity in Cisd2hKO-het mice (heterozygous hepatocyte-specific Cisd2 knockout) . Cisd2 (CDGSH iron sulfur domain 2) is a zinc finger protein that is mainly localized in the endoplasmic reticulum or mitochondrial membrane. Cisd2 participates in mitochondrial function by forming homodimers containing two redox-active 2Fe-2S clusters[1][2].

Product Specifications

CAS Number

[2916371-59-8]

UNSPSC

12352005

Target

IKZF Family; Zinc Finger Protein

Type

Reference compound

Related Pathways

Cell Cycle/DNA Damage; Immunology/Inflammation

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/cisd2-agonist-2.html

Purity

99.17

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

NC1=C(C(OC)=O)C(C)=C(C(NC2=CC=C(C=C2)O)=O)S1

Molecular Formula

C14H14N2O4S

Molecular Weight

306.34

References & Citations

[1]Yao CH, et al. Discovery of tetrasubstituted thiophenes as Cisd2 activators: A potential novel therapeutic option in nonalcoholic fatty liver disease. Eur J Med Chem. 2023 Oct 5;258:115583.|[2]Li J, et al. CDGSH Iron Sulfur Domain 2 Deficiency Inhibits Cell Proliferation and Induces Cell Differentiation of Neuroblastoma. Pathol Oncol Res. 2020 Jul;26 (3) :1725-1733.