Cisd2 agonist 2
Cisd2 agonist 2 (compound 6) is a Cisd2 activator (EC50=191 nM), and Cisd2 levels are associated with non-alcoholic fatty liver disease (NAFLD) . Cisd2 agonist 2 has no significant in vivo toxicity in Cisd2hKO-het mice (heterozygous hepatocyte-specific Cisd2 knockout) . Cisd2 (CDGSH iron sulfur domain 2) is a zinc finger protein that is mainly localized in the endoplasmic reticulum or mitochondrial membrane. Cisd2 participates in mitochondrial function by forming homodimers containing two redox-active 2Fe-2S clusters[1][2].
Product Specifications
CAS Number
[2916371-59-8]
UNSPSC
12352005
Target
IKZF Family; Zinc Finger Protein
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage; Immunology/Inflammation
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/cisd2-agonist-2.html
Purity
99.17
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
NC1=C(C(OC)=O)C(C)=C(C(NC2=CC=C(C=C2)O)=O)S1
Molecular Formula
C14H14N2O4S
Molecular Weight
306.34
References & Citations
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
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