Alloc-DOX

Alloc-DOX (N-Alloc doxorubicin) is a Doxorubicin (HY-15142A) prodrug. The combination of a catalyst (such as nano-palladium) and alloc-DOX leads to a decrease in cell viability and tumour growth[1][2].

Product Specifications

CAS Number

[561022-65-9]

Product Name Alternative

N-Alloc doxorubicin

UNSPSC

12352005

Target

AMPK; Antibiotic; Apoptosis; Autophagy; Bacterial; HBV; HIV; Mitophagy; Topoisomerase

Type

Reference compound

Related Pathways

Anti-infection; Apoptosis; Autophagy; Cell Cycle/DNA Damage; Epigenetics; PI3K/Akt/mTOR

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/alloc-dox.html

Purity

98.40

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

OC1=C(C(C2=CC=CC(OC)=C2C3=O)=O)C3=C(O)C4=C1C[C@](C(CO)=O)(O)C[C@@H]4O[C@H]5C[C@@H]([C@@H]([C@@H](O5)C)O)NC(OCC=C)=O

Molecular Formula

C31H33NO13

Molecular Weight

627.59

References & Citations

[1]Miller MA, et al. Nano-palladium is a cellular catalyst for in vivo chemistry. Nat Commun. 2017 Jul 12;8:15906. |[2]Chen Z, et al. Bioorthogonal catalytic patch. Nat Nanotechnol. 2021 Aug;16 (8) :933-941.