Allitinib tosylate
Allitinib tosylate (AST-1306 (TsOH) ) is an orally active and irreversible EGFR and ErbB2 inhibitor with IC50s of 0.5 and 3 nM, respectively. Allitinib tosylate also inhibits ErbB4 with an IC50 of 0.8 nM. Allitinib tosylate is an anilino-quinazoline compound and has anti-cancer activity[1]
Product Specifications
CAS Number
1050500-29-2
Product Name Alternative
AST-1306 (TsOH)
UNSPSC
12352005
Hazard Statement
H301, H311, H331, H341
Target
EGFR
Type
Reference compound
Related Pathways
JAK/STAT Signaling; Protein Tyrosine Kinase/RTK
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/ast-1306-tsoh.html
Concentration
10mM
Purity
99.54
Solubility
DMSO : 50 mg/mL (ultrasonic)
Smiles
FC1=CC=CC(COC2=C(Cl)C=C(NC3=NC=NC4=C3C=C(NC(C=C)=O)C=C4)C=C2)=C1.O=S(C5=CC=C(C)C=C5)(O)=O
Molecular Formula
C31H26ClFN4O5S
Molecular Weight
621.08
Precautions
H301, H311, H331, H341
References & Citations
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
EGFR/ErbB1/HER1; ErbB2/HER2; ErbB4/HER4
Citation 01
Sci Data. 2024 Sep 19;11 (1) :1024.|Cell Rep. 2025 Apr 16;44 (5) :115572.
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