Pyrazoloadenine
Pyrazoloadenine is a potent RET (REarranged during Transfection) lung cancer oncoprotein inhibitor. Pyrazoloadenine shows anticancer activity[1][2].
Product Specifications
CAS Number
[2380-63-4]
UNSPSC
12352005
Hazard Statement
H301, H315, H319, H335
Target
RET
Type
Reference compound
Related Pathways
Protein Tyrosine Kinase/RTK
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/pyrazoloadenine.html
Purity
99.98
Solubility
DMSO : 5 mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
NC1=C2C(NN=C2)=NC=N1
Molecular Formula
C5H5N5
Molecular Weight
135.13
Precautions
H301, H315, H319, H335
References & Citations
[1]Saha D, et al. Pyrazoloadenine Inhibitors of the RET Lung Cancer Oncoprotein Discovered by a Fragment Optimization Approach. ChemMedChem. 2021 May 18;16 (10) :1605-1608.|[2]SKIPPER HE, et al. Inhibition of experimental neoplasms by 4-aminopyrazolo (3, 4-d) pyrimidine. Proc Soc Exp Biol Med. 1955 Aug;89 (4) :594-6.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, protect from light)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Curated Selection
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