Catharanthine (Tartrate)
Catharanthine ((+) -3,4-Didehydrocoronaridine) Tartrate, a constituent of anticancer vinca alkaloids, inhibits voltage-operated L-type Ca2+ channel (VOCC) . Catharanthine Tartrate has IC50s of 220 μM and 8 μM for VOCC currents in cardiomyocytes and vascular smooth muscle cells (VSMCs), respectively. Catharanthine Tartrate lowers blood pressure (BP), heart rate (HR) . Catharanthine Tartrate has anti-cancer activity[1][2].
Product Specifications
CAS Number
4168-17-6
Product Name Alternative
(+) -3,4-Didehydrocoronaridine (Tartrate)
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Calcium Channel
Type
Natural Products
Related Pathways
Membrane Transporter/Ion Channel; Neuronal Signaling
Applications
Cancer-programmed cell death
Field of Research
Cancer; Neurological Disease; Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/catharanthine-tartrate.html
Purity
98.88
Solubility
DMSO : 100 mg/mL (ultrasonic) |H2O : 5 mg/mL (ultrasonic; warming; adjust pH to 3 with HCl; heat to 60°C)
Smiles
O=C([C@@]1(C2=C3C(C=CC=C4)=C4N2)[C@](C(CC)=C5)([H])[N@](CC3)C[C@]5([H])C1)OC.O[C@@H](C(O)=O)[C@H](C(O)=O)O
Molecular Formula
C25H30N2O8
Molecular Weight
486.51
Precautions
H302, H315, H319, H335
References & Citations
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture and light)
Scientific Category
Natural Products
Clinical Information
No Development Reported
Isoform
L-type calcium channel
Citation 01
Cell Signal. 2025 Mar 29:111779.|Ind Crops Prod. 2025 Aug.
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