PF-06305591
PF-06305591 is a potent and highly selective voltage gated sodium channel NaV1.8 blocker, with an IC50 of 15 nM. An excellent preclinical in vitro ADME and safety profile[1].
Product Specifications
CAS Number
[1449473-97-5]
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Sodium Channel
Type
Reference compound
Related Pathways
Membrane Transporter/Ion Channel
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/PF-06305591.html
Purity
99.74
Solubility
DMSO : 140 mg/mL (ultrasonic)
Smiles
CC(C)(C)C1=CC=C(NC([C@H]([C@@H](C)C(N)=O)N)=N2)C2=C1
Molecular Formula
C15H22N4O
Molecular Weight
274.37
Precautions
H302, H315, H319, H335
References & Citations
[1]Brown AD, et al. The discovery and optimization of benzimidazoles as selective NaV1.8 blockers for the treatment of pain. Bioorg Med Chem. 2019 Jan 1;27 (1) :230-239.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Phase 1
Isoform
Nav1.8
Available Sizes
Curated Selection
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