Nicorandil

Nicorandil (SG-75) is a potent potassium channel activator and targets vascular nucleoside diphosphate-dependent K+ channels and cardiac ATP-sensitive K+ channels (KATP) . Nicorandil is a nicotinamide ester with vasodilatory and cardioprotective effects and has the potential for angina and forischemic heart diseases[1][2][3].

Product Specifications

CAS Number

[65141-46-0]

Product Name Alternative

SG-75

UNSPSC

12352005

Hazard Statement

H302, H318

Target

Potassium Channel

Type

Reference compound

Related Pathways

Membrane Transporter/Ion Channel

Applications

COVID-19-immunoregulation

Field of Research

Cardiovascular Disease

Assay Protocol

https://www.medchemexpress.com/Nicorandil.html

Purity

98.20

Solubility

DMSO : 100 mg/mL|H2O : ≥ 20 mg/mL

Smiles

O=C(C1=CC=CN=C1)NCCO[N+]([O-])=O

Molecular Formula

C8H9N3O4

Molecular Weight

211.17

Precautions

H302, H318

References & Citations

[1]Nakae, I., et al., Effects of intravenous nicorandil on coronary circulation in humans: plasma concentration and action mechanism. J Cardiovasc Pharmacol, 2000. 35 (6) : p. 919-25.|[2]Sauzeau, V., et al., Cyclic GMP-dependent protein kinase signaling pathway inhibits RhoA-induced Ca2+ sensitization of contraction in vascular smooth muscle. J Biol Chem, 2000. 275 (28) : p. 21722-9.|[3]Mitsuhiko Yamada, et al. The nucleotide-binding domains of sulfonylurea receptor 2A and 2B play different functional roles in nicorandil-induced activation of ATP-sensitive K+ channels. Mol Pharmacol. 2004 May;65 (5) :1198-207.