Bactenecin (TFA)

Bactenecin TFA (Bactenecin, bovine TFA) is a potent 12-aa looped antimicrobial peptide isolated from bovine neutrophils. Bactenecin TFA inhibits the growth of bacteria and yeast, and kills the fungus Trichophyton rubrum. Bactenecin TFA increass membrane permeability, inhibits the growth and biofilm formation of B. pseudomallei[1][2][3].

Product Specifications

Product Name Alternative

Bactenecin, bovine (TFA)

UNSPSC

12352209

Target

Bacterial; Fungal

Type

Peptides

Related Pathways

Anti-infection

Applications

COVID-19-immunoregulation

Field of Research

Infection

Assay Protocol

https://www.medchemexpress.com/bactenecin-tfa.html

Purity

98.02

Solubility

H2O : 100 mg/mL (ultrasonic)

Smiles

O=C(O)C(F)(F)F.O=C(N[C@@H](CC(C)C)C(N[C@@H](CSSC[C@@H](C(N[C@@H](CCCNC(N)=N)C(O)=O)=O)NC1=O)C(N[C@@H](CCCNC(N)=N)C(N[C@@H]([C@@H](C)CC)C(N[C@@H](C(C)C)C(N[C@@H](C(C)C)C(N[C@@H]([C@@H](C)CC)C(N[C@@H](CCCNC(N)=N)C(N[C@H]1C(C)C)=O)=O)=O)=O)=O)=O)=O)=O)[C@H](CCCNC(N)=N)N

Molecular Formula

C65H119F3N24O15S2

Molecular Weight

1597.94

References & Citations

[1]Gallis B, et al. Antimicrobial activity of synthetic bactenecin. Biotechnol Ther. 1989-1990;1 (4) :335-46.|[2]Radermacher SW, et al. Bactenecin, a leukocytic antimicrobial peptide, is cytotoxic to neuronal and glial cells. J Neurosci Res. 1993 Dec 15;36 (6) :657-62.|[3]Kanjana Madhongsa, et al. Antimicrobial Action of the Cyclic Peptide Bactenecin on Burkholderia Pseudomallei Correlates With Efficient Membrane Permeabilization. PLoS Negl Trop Dis. 2013 Jun 13;7 (6) :e2267.