(S, R, S) -AHPC-PEG1-NH2 (dihydrochloride)
(S, R, S) -AHPC-PEG1-NH2 (VH032-PEG1-NH2) dihydrochloride incorporates a VHL ligand for the E3 ubiquitin ligase and a PROTAC linker. (S, R, S) -AHPC-PEG1-NH2 dihydrochloride can be used to design PROTACs[1].
Product Specifications
CAS Number
[2341796-83-4]
Product Name Alternative
VH032-PEG1-NH2 (dihydrochloride)
UNSPSC
12352005
Hazard Statement
H302-H315-H319-H335
Target
E3 Ligase Ligand-Linker Conjugates
Type
Reference compound
Related Pathways
PROTAC
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/vh032-peg1-nh2-dihydrochloride.html
Solubility
10 mM in DMSO
Smiles
O=C(N(C[C@H](O)C1)[C@@H]1C(NCC2=CC=C(C(SC=N3)=C3C)C=C2)=O)[C@H](C(C)(C)C)NC(COCCN)=O.Cl.Cl
Molecular Formula
C26H39Cl2N5O5S
Molecular Weight
604.59
Precautions
P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501
References & Citations
[1]Jing Liu, et al. Tropomyosin receptor kinase (trk) degradation compounds and methods of use. WO2020038415A1.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
Von Hippel-Lindau (VHL)
Available Sizes
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