MT-DADMe-ImmA

MT-DADMe-ImmA is an inhibitor of human 5'-methylthioadenosine phosphorylase (MTAP) with a Ki of 90 pM.

Product Specifications

CAS Number

[653592-04-2]

Product Name Alternative

MTDIA; Methylthio-DADMe-Immucillin A

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Histone Methyltransferase

Type

Reference compound

Related Pathways

Epigenetics

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/MT-DADMe-ImmA.html

Purity

98.42

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

O[C@H]1CN(CC2=CNC3=C(N)N=CN=C32)C[C@@H]1CSC

Molecular Formula

C13H19N5OS

Molecular Weight

293.40

Precautions

H302, H315, H319, H335

References & Citations

[1]Evans GB, et al. Second generation transition state analogue inhibitors of human 5'-methylthioadenosine phosphorylase. J Med Chem. 2005 Jul 14;48 (14) :4679-89.|[2]Basu I, et al. A transition state analogue of 5'-methylthioadenosine phosphorylase induces apoptosis in head and neck cancers. J Biol Chem. 2007 Jul 20;282 (29) :21477-86.