CGS 20625

CGS 20625 is a potent, selective and orally active partial agonist for the central benzodiazepine receptor. CGS 20625 inhibits [3H]-flunitrazepam binding to central benzodiazepine receptors with an IC50 of 1.3 nM. CGS 20625 enhances GABA in Xenopus laevis oocytes . CGS 20625 can be used for the research of pentylenetetrazol-induced seizures and anxiety[1][2].

Product Specifications

CAS Number

[111205-55-1]

UNSPSC

12352005

Target

GABA Receptor

Type

Reference compound

Related Pathways

Membrane Transporter/Ion Channel; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/cgs-20625.html

Purity

99.80

Solubility

DMSO : 50 mg/mL (ultrasonic; warming; heat to 60°C)

Smiles

O=C1C2=CNC(CCCCC3)=C3C2=NN1C4=CC=C(OC)C=C4

Molecular Formula

C18H19N3O2

Molecular Weight

309.36

References & Citations

[1]Williams M, et al. CGS 20625, a novel pyrazolopyridine anxiolytic. J Pharmacol Exp Ther. 1989 Jan;248 (1) :89-96.|[2]Khom S, et al. Pharmacological properties of GABAA receptors containing gamma1 subunits. Mol Pharmacol. 2006 Feb;69 (2) :640-9.