VJDT

VJDT is a TREM1 inhibitor that can effectively block TREM1 signaling. VJDT inhibits tumor cell proliferation and migration and induces cell cycle arrest. VJDT has immunomodulatory and antitumor activities, and can be used for the research of tumors such as melanoma[1].

Product Specifications

CAS Number

[2765319-65-9]

UNSPSC

12352005

Target

Akt; Interleukin Related; NF-κB; PI3K; Transmembrane Glycoprotein; TREM receptor

Type

Reference compound

Related Pathways

Immunology/Inflammation; NF-κB; PI3K/Akt/mTOR

Applications

Cancer-programmed cell death

Field of Research

Cancer; Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/vjdt.html

Purity

99.68

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

O=C(N1CC2=CC=CC=C2)[C@@H]3C=C(C#N)[C@H]1C(C(N4C5=CC=CC=C5)=O)C3C4=O

Molecular Formula

C23H17N3O3

Molecular Weight

383.40

References & Citations

[1]Ajith A, et al. Targeting TREM1 augments antitumor T cell immunity by inhibiting myeloid-derived suppressor cells and restraining anti-PD-1 resistance. J Clin Invest. 2023 Nov 1;133 (21) :e167951.