MK2a Inhibitor (Highly Pure)

<strong>MK2a Inhibitor (Highly Pure)</strong>_x000D_ <strong>Catalog number:</strong> B2012568_x000D_ <strong>Lot number:</strong> Batch Dependent_x000D_ <strong>Expiration Date:</strong> Batch dependent_x000D_ <strong>Amount:</strong> 1 mg_x000D_ <strong>Molecular Weight or Concentration:</strong> 349.4 g/mol_x000D_ <strong>Supplied as:</strong> Lyophilized Powder_x000D_ <strong>Applications:</strong> molecular tool for various biochemical applications_x000D_ <strong>Storage:</strong> -20°C_x000D_ <strong>Keywords:</strong> CMPD 1, 2'-fluoro-N-(4-hydroxyphenyl)-[1,1'-biphenyl]-4-butanamide_x000D_ <strong>Grade:</strong> Biotechnology grade. All products are highly pure. All solutions are made with Type I ultrapure water (resistivity &gt;18 MΩ-cm) and are filtered through 0.22 um._x000D_ _x000D_ <strong>References:</strong>_x000D_ 1: Brugnano J, McMasters J, Panitch A. Characterization of endocytic uptake of MK2-inhibitor peptides J Pept Sci. 2013 Oct;19(10):629-38._x000D_ 2: Ronkina N, Kotlyarov A, Gaestel M. MK2 and MK3--a pair of isoenzymes? Front Biosci. 2008 May 1;13:5511-21._x000D_ 3: Brugnano JL, Panitch A. Matrix stiffness affects endocytic uptake of MK2-inhibitor peptides PLoS One. 2014 Jan 6;9(1):e84821._x000D_ 4: Hugon J, Paquet C. The PKR/P38/RIPK1 Signaling Pathway as a Therapeutic Target in Alzheimer's Disease Int J Mol Sci. 2021 Mar 19;22(6):3136._x000D_ 5: Chen IT, Chen HC, Lo YH, Lai PY, Hsieh FY, Wu YH, Shih HM, Lai MZ. Promyelocytic leukemia protein targets MK2 to promote cytotoxicity EMBO Rep. 2021 Dec 6;22(12):e52254._x000D_ 6: Fujino A, Fukushima K, Namiki N, Kosugi T, Takimoto-Kamimura M. Structural analysis of an MK2-inhibitor complex: insight into the regulation of the secondary structure of the Gly-rich loop by TEI-I01800 Acta Crystallogr D Biol Crystallogr. 2010 Jan;66(Pt 1):80-7._x000D_ 7: Duraisamy S, Bajpai M, Bughani U, Dastidar SG, Ray A, Chopra P. MK2: a novel molecular target for anti-inflammatory therapy Expert Opin Ther Targets. 2008 Aug;12(8):921-36._x000D_ 8: Ruiz M, Coderre L, Allen BG, Des Rosiers C. Protecting the heart through MK2 modulation, toward a role in diabetic cardiomyopathy and lipid metabolism Biochim Biophys Acta Mol Basis Dis. 2018 May;1864(5 Pt B):1914-1922._x000D_ 9: Ray AL, Berggren KL, Restrepo Cruz S, Gan GN, Beswick EJ. Inhibition of MK2 suppresses IL-1β, IL-6, and TNF-α-dependent colorectal cancer growth Int J Cancer. 2018 Apr 15;142(8):1702-1711._x000D_ <a href="https://pubmed.ncbi.nlm.nih.gov/34140814">10: Gordon D, Hellriegel ET, Hope HR, Burt D, Monahan JB. Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of the MK2 Inhibitor ATI-450 in Healthy Subjects: A Placebo-Controlled, Randomized Phase 1 Study Clin Pharmacol. 2021 Jun 10;13:123-134. </a>_x000D_ _x000D_ <strong>Products Related to MK2a Inhibitor (Highly Pure) can be found at</strong> <a href="https://moleculardepot.com/product-category/Chemicals/"> Chemicals</a>