CB1 antagonist 5

CB1 antagonist 5 (Compound 25) is an antagonist for CB1 cannabinoid receptor, with a Ki of 243 nM and an EC50 of 195 nM[1].

Product Specifications

CAS Number

[878533-35-8]

UNSPSC

12352005

Hazard Statement

H302-H315-H319-H335

Target

Cannabinoid Receptor

Type

Reference compound

Related Pathways

GPCR/G Protein; Neuronal Signaling

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/cb1-antagonist-5.html

Smiles

O=C1N(C(C(N1C2=CC=C(C=C2)Br)C3=CC=CC=C3)=O)C4=CC=C(C=C4)Br

Molecular Formula

C21H14Br2N2O2

Molecular Weight

486.16

Precautions

P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

References & Citations

[1]Muccioli GG, et al., Synthesis and activity of 1,3,5-triphenylimidazolidine-2,4-diones and 1,3,5-triphenyl-2-thioxoimidazolidin-4-ones: characterization of new CB1 cannabinoid receptor inverse agonists/antagonists. J Med Chem. 2006 Feb 9;49 (3) :872-82.