Zapalog

Zapalog is a photocleavable small-molecule heterodimerizer that can be used to repeatedly initiate, and instantaneously terminate, a physical interaction between two target proteins. Zapalog dimerizes any two proteins tagged with the FKBP and DHFR domains until exposure to light causes its photolysis[1].

Product Specifications

CAS Number

[1708091-24-0]

UNSPSC

12352005

Target

FKBP

Type

Reference compound

Related Pathways

Apoptosis; Autophagy; Cell Cycle/DNA Damage; Immunology/Inflammation

Applications

COVID-19-immunoregulation

Field of Research

Others

Assay Protocol

https://www.medchemexpress.com/zapalog.html

Purity

99.62

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

O=C([C@H]1N(C(C(C(C)(C)CC)=O)=O)CCCC1)O[C@@H](C2=CC=CC(NC(CCCOC3=CC([N+]([O-])=O)=C(C(OCCOC4=C(OC)C=C(CC5=CN=C(N)N=C5N)C=C4OC)C)C=C3OC)=O)=C2)CCC6=CC=C(OC)C(OC)=C6

Molecular Formula

C58H73N7O15

Molecular Weight

1108.24

References & Citations

[1]Gutnick A, et al. The light-sensitive dimerizer zapalog reveals distinct modes of immobilization for axonal mitochondria. Nat Cell Biol. 2019 Jun;21 (6) :768-777.