Picosulfate (sodium salt hydrate)

Picosulfate sodium salt hydrate is the hydrate of Sodium Picosulfate (HY-B0544) . Picosulfate sodium salt hydrate is an orally active contact irritant laxative. Picosulfate sodium salt hydrate inhibits the absorption of water and electrolytes, increasing their production. Picosulfate sodium salt hydrate can be used in colonoscopy applications[1][2][3][4].

Product Specifications

CAS Number

[1307301-38-7]

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Others

Type

Reference compound

Related Pathways

Others

Field of Research

Metabolic Disease

Assay Protocol

https://www.medchemexpress.com/picosulfate-sodium-salt-hydrate.html

Purity

98.0

Smiles

O=S(OC(C=C1)=CC=C1C(C2=CC=CC=N2)C3=CC=C(OS(=O)(O[Na])=O)C=C3)(O[Na])=O.O

Molecular Formula

C18H15NNa2O9S2

Molecular Weight

499.42

Precautions

H302, H315, H319, H335

References & Citations

[1]Nishikawa J, et al. Toxicity study with sodium picosulfate in cultured liver cells of rabbit, rat and man. Arzneimittelforschung. 1981;31 (2) :321-5.|[2]Geboes K, et al. Effects of 'contact laxatives' on intestinal and colonic epithelial cell proliferation. Pharmacology. 1993 Oct;47 Suppl 1:187-95.|[3]Fioramonti J, et al. In vivo motility of rat colon chronically pretreated with sennosides. Pharmacology. 1993 Oct;47 Suppl 1:155-61.|[4]Regev A, et al. Comparison of two bowel preparations for colonoscopy: sodium picosulphate with magnesium citrate versus sulphate-free polyethylene glycol lavage solution. Am J Gastroenterol. 1998 Sep;93 (9) :1478-82.