UCB9608

UCB9608 is a potent, selective and orally active PI4KIIIβ inhibitor, with an IC50 of 11 nM, selective over PI3KC2 α, β, and γ lipid kinases. UCB9608 improves metabolic stability and exhibits excellent pharmacokinetic profile, acts as a potent immunosuppressive agent[1].

Product Specifications

CAS Number

[1616413-96-7]

UNSPSC

12352005

Hazard Statement

H302

Target

PI4K

Type

Reference compound

Related Pathways

PI3K/Akt/mTOR

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/UCB9608.html

Concentration

10mM

Purity

99.59

Solubility

DMSO : 65 mg/mL (ultrasonic)

Smiles

NC1=NC(N2CCN(C(NC3=CC=C(OC)C=C3C)=O)C[C@@H]2C)=C4C(N(C)N=C4)=N1

Molecular Formula

C20H26N8O2

Molecular Weight

410.47

Precautions

H302

References & Citations

[1]Reuberson J, et al. Discovery of a Potent, Orally Bioavailable PI4KIIIβ Inhibitor (UCB9608) Able To Significantly Prolong Allogeneic Organ Engraftment in Vivo. J Med Chem. 2018 Aug 9;61 (15) :6705-6723.