Amiodarone

Amiodarone is an antiarrhythmic agent for inhibition of ATP-sensitive potassium channel with an IC50 of 19.1 μM.

Product Specifications

CAS Number

[1951-25-3]

UNSPSC

12352005

Hazard Statement

H315, H319, H320

Target

Autophagy; Potassium Channel

Type

Reference compound

Related Pathways

Autophagy; Membrane Transporter/Ion Channel

Applications

Cancer-programmed cell death

Field of Research

Cardiovascular Disease; Cancer

Assay Protocol

https://www.medchemexpress.com/Amiodarone.html

Purity

98.32

Solubility

DMSO : ≥ 175 mg/mL

Smiles

CCCCC1=C(C(C2=CC(I)=C(OCCN(CC)CC)C(I)=C2)=O)C3=C(O1)C=CC=C3

Molecular Formula

C25H29I2NO3

Molecular Weight

645.31

Precautions

H315, H319, H320

References & Citations

[1]Singh, B.N. and E.M. Vaughan Williams, The effect of amiodarone, a new anti-anginal drug, on cardiac muscle. Br J Pharmacol, 1970. 39 (4) : p. 657-67.|[2]Rosenbaum, M.B., et al., Clinical efficacy of amiodarone as an antiarrhythmic agent. Am J Cardiol, 1976. 38 (7) : p. 934-44.|[3]Wilson BD, et al. Amiodarone-induced pulmonary toxicity in the rat. Lung. 1989;167 (5) :301-11.|[4]Plomp TA, et al. Pharmacokinetics and body distribution of amiodarone and desethylamiodarone in rats after oral administration. In Vivo. 1987 Sep-Oct;1 (5) :265-79.|[5]Takai S, et al. Establishment of a mouse model for amiodarone-induced liver injury and analyses of its hepatotoxic mechanism. J Appl Toxicol. 2016 Jan;36 (1) :35-47.