Daurisoline-d11
Daurisoline-d11 is the deuterium labeled Daurisoline. Daurisoline is a bis-benzylisoquinoline alkaloid that can be isolated from Menispermum dauricum and Rhizoma Menispermi. Daurisoline exerts a blocking effect on hERG and has antiarrhythmic effects. Daurisoline is a potent autophagy blocker that can be used for the research of cancer[1][2].
Product Specifications
Product Name Alternative
(R, R) -Daurisoline-d11
UNSPSC
12352005
Target
Autophagy; Isotope-Labeled Compounds; Potassium Channel
Type
Isotope-Labeled Compounds
Related Pathways
Autophagy; Membrane Transporter/Ion Channel; Others
Applications
COVID-19-immunoregulation
Field of Research
Cancer
Solubility
10 mM in DMSO
Smiles
OC1=C(C2=C(CCN([C@@H]2CC3=C(C([2H])=C(C(OC4=C(C([2H])=C(C([2H])=C4[2H])C[C@H]5N(CCC6=C5C([2H])=C(C(OC)=C6[2H])OC)C)[2H])=C3[2H])O)[2H])C)C([2H])=C1OC)[2H]
Molecular Formula
C37H31D11N2O6
Molecular Weight
621.81
References & Citations
[1]Liu Q, et al. Effect of daurisoline on HERG channel electrophysiological function and protein expression. J Nat Prod. 2012 Sep 28;75 (9) :1539-45. |[2]Wu MY, et al. Natural autophagy blockers, dauricine (DAC) and daurisoline (DAS), sensitize cancer cells to camptothecin-induced toxicity. Oncotarget. 2017 Sep 8;8 (44) :77673-77684.
Shipping Conditions
Room temperature
Scientific Category
Isotope-Labeled Compounds
Clinical Information
No Development Reported
Frequently Asked Questions
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