What is the catalog number for Dioscin?

The catalog number for Dioscin is HY-N0124.

What sizes are available for Dioscin?

Dioscin is available in the following size(s): 5 mg, 10 mM - 1 mL, 10 mg, 50 mg, 100 mg.

How many pack sizes does Dioscin come in?

Dioscin is available in 5 different pack sizes.

Dioscin is currently made to order / not held in immediate stock. Contact us for lead time.

Who manufactures Dioscin?

Dioscin is manufactured by QuantiMol.

What is the estimated delivery time for Dioscin?

Estimated delivery time for Dioscin is approximately 15 business day(s), depending on your location.

Where can I find the safety data sheet (SDS/MSDS) for Dioscin?

The safety data sheet for Dioscin is available here: http://file.medchemexpress.com/batch_PDF/HY-N0124/Dioscin-SDS-MedChemExpress.pdf.

Dioscin

Dioscin (CCRIS 4123; Collettiside III) is a natural plant-derived steroidal saponin that has good anti-cancer activity against a variety of cancer cells. Dioscin causes DNA damage and induces apoptosis in HeLa and SiHa cells. Dioscin regulates ROS-mediated DNA damage and mitochondrial signaling pathways, exerting anticancer activity[1][2][3][4][5][6].

Product Specifications

CAS Number

19057-60-4

Product Name Alternative

Collettiside III; CCRIS 4123

UNSPSC

12352005

Hazard Statement

H315, H319

Target

Apoptosis; Autophagy

Type

Natural Products

Related Pathways

Apoptosis; Autophagy

Applications

Cancer-Kinase/protease

Field of Research

Cancer; Cardiovascular Disease

Assay Protocol

https://www.medchemexpress.com/Dioscin.html

Purity

99.95

Solubility

DMSO : ≥ 100 mg/mL

Smiles

O[C@@H]1[C@@H](O)[C@H](C)O[C@@]([H])(O[C@H]2[C@H](O)[C@@H](O[C@]3([H])O[C@@H](C)[C@H](O)[C@@H](O)[C@H]3O)[C@@](O[C@@H]4CC5=CC[C@]([C@]([H])(C[C@@]6([H])[C@]7([H])[C@H](C)[C@]8(OC[C@H](C)CC8)O6)[C@]7(C)CC9)([H])[C@@]9([H])[C@@]5(C)CC4)([H])O[C@@H]2CO)[C@@H]1O

Molecular Formula

C45H72O16

Molecular Weight

869.04

Precautions

H315, H319

References & Citations

[1]Chen J, et al. Dioscin-induced apoptosis of human LNCaP prostate carcinoma cells through activation of caspase-3 and modulation of Bcl-2 protein family. J Huazhong Univ Sci Technolog Med Sci. 2014 Feb;34 (1) :125-30.|[2]Qu X, et al. Dioscin inhibits osteoclast differentiation and bone resorption though down-regulating the Akt signaling cascades. Biochem Biophys Res Commun. 2014 Jan 10;443 (2) :658-65.|[3]Qin J, et al. Dioscin prevents the mitochondrial apoptosis and attenuates oxidative stress in cardiac H9c2 cells. Drug Res (Stuttg) . 2014 Jan;64 (1) :47-52.|[4]Zhao X, et al. Dioscin Induces Apoptosis in Human Cervical Carcinoma HeLa and SiHa Cells through ROS-Mediated DNA Damage and the Mitochondrial Signaling Pathway. Molecules. 2016 Jun 4;21 (6) :730.|[5]Xu T, et al. A 90-day subchronic toxicological assessment of dioscin, a natural steroid saponin, in Sprague-Dawley rats. Food Chem Toxicol. 2012 May;50 (5) :1279-87.|[6]Tao X, et al. Dioscin attenuates hepatic ischemia-reperfusion injury in rats through inhibition of oxidative-nitrative stress, inflammation and apoptosis. Transplantation. 2014 Sep 27;98 (6) :604-11.