HDHODH-IN-4

HDHODH-IN-4 is a potent human dihydroorotate dehydrogenase (DHODH) inhibitor, with a pIC50 of 7.8 for human recombinant DHODH. hDHODH-IN-4 inhibits measles virus replication, with a pMIC50 of 8.8[1].

Product Specifications

CAS Number

[1644156-56-8]

UNSPSC

12352005

Target

Dihydroorotate Dehydrogenase; DNA/RNA Synthesis; Influenza Virus

Type

Reference compound

Related Pathways

Anti-infection; Cell Cycle/DNA Damage; Metabolic Enzyme/Protease

Applications

COVID-19-anti-virus

Field of Research

Infection

Assay Protocol

https://www.medchemexpress.com/dhodh-in-5.html

Concentration

10mM

Purity

99.73

Solubility

DMSO : 125 mg/mL (ultrasonic)

Smiles

OC(C1=CC=CC=C1)C2=C(C)N(C3=NC=C(C4CC4)C=N3)N=C2OC(C)C

Molecular Formula

C21H24N4O2

Molecular Weight

364.44

References & Citations

[1]Munier-Lehmann H, et al. Original 2- (3-alkoxy-1H-pyrazol-1-yl) pyrimidine derivatives as inhibitors of human dihydroorotate dehydrogenase (DHODH) . J Med Chem. 2015 Jan 22;58 (2) :860-77.