Stafib-1
Stafib-1 is the first selective inhibitor of the STAT5b SH2 domain, with a Ki of 44 nM and an IC50 of 154 nM[1].
Product Specifications
CAS Number
1688703-26-5
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
STAT
Type
Reference compound
Related Pathways
JAK/STAT Signaling; Stem Cell/Wnt
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/stafib-1.html
Purity
99.25
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O=C(C1=CC=C2C=C(OCC(NCC3=CC=C(OP(O)(O)=O)C(OP(O)(O)=O)=C3)=O)C=CC2=C1)NC4=CC=CC=C4
Molecular Formula
C26H24N2O11P2
Molecular Weight
602.42
Precautions
H302, H315, H319, H335
References & Citations
[1]Nagarajan Elumalai, et al. Rational development of Stafib-2: a selective, nanomolar inhibitor of the transcription factor STAT5b. Sci Rep. 2017 Apr 11;7 (1) :819.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
STAT5
Available Sizes
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